产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

Bax (S4) polyclonal antibody（KU）

货号: BS1030

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1030

Product Name :Bax (S4) polyclonal antibody（KU）

Swiss-Prot :Q07812

Host :Rabbit

Reactivity :Human

Applications :WB IHC IP

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IP: 1:50~1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bax (S4) polyclonal antibody detects endogenous levels of Bax protein.

BiowMW :~ 21 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4

Immunogen :Synthetic peptide, corresponding to the N-terminus of Human Bax.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Bax (S4) polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate(40ug) Lane2:K562 whole cell lysate(40ug) Lane3:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Bax (S4) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.

Immunoprecipitation of A549 cell lysates using Bax (S4) pAb (Sepharose Bead Conjugate)#BD0048 (lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate)#BD0048 (lane 4 and lane 5) .Lane 1 is 30% input. The western blot was probed using Bax (S4) pAb #BS1030.

Autophagy promotes fibrosis and apoptosis in the peritoneum during long‐term peritoneal dialysis

JournalJournal Of Cellular And Molecular Medicine

ApplicationWB

IF4.658

SpeciesHuman

PMID29077259
Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells

JournalBiomedicine & Pharmacotherapy

ApplicationWB

IF4.545

SpeciesHuman

PMID
DYT-40, a novel synthetic 2-styryl-5-nitroimidazole derivative, blocks malignant glioblastoma growth and invasion by inhibiting AEG-1 and NF-κB signaling pathways

JournalScientific Reports

ApplicationWB

IF4.011

SpeciesHuman

PMID27251589
MicroRNA‐3178 ameliorates inflammation and gastric carcinogenesis promoted by Helicobacter pylori new toxin, Tip‐α, by targeting TRAF3

JournalHelicobacter

ApplicationWB

IF3.352

SpeciesHuman

PMID27493095
Curcumin activates autophagy and attenuates oxidative damage in EA.hy926 cells via the Akt/mTOR pathway

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesHuman

PMID26781771