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MMP9 polyclonal antibody

货号: BS6893

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6893

Product Name :MMP9 polyclonal antibody

Swiss-Prot :P14780

Host :Rabbit

Reactivity :Human,Mouse

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMP9 polyclonal antibody detects endogenous levels of MMP9 protein.

BiowMW :~ 67 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB; MMP9; CLG4B

Immunogen :Recombinant full length Human MMP9.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded mouse heart using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human liver damage using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse liver using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse kidney using MMP9 antibody at dilution of 1:100 (40x lens).

Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID28424406
Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression

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IF0

SpeciesHuman

PMID27270327
LncRNA-SVUGP2 suppresses progression of hepatocellular carcinoma

JournalOncotarget

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IF0

SpeciesHuman

PMID29228655
Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID29050260
Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID26396173