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MMP9 polyclonal antibody

货号: BS6893

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS6893

Product Name :MMP9 polyclonal antibody

Swiss-Prot :P14780

Host :Rabbit

Reactivity :Human,Mouse

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or taphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MMP9 polyclonal antibody detects endogenous levels of MMP9 protein.

BiowMW :~ 67 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Matrix metalloproteinase-9; MMP-9; 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB; MMP9; CLG4B

Immunogen :Recombinant full length Human MMP9.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry of paraffin-embedded mouse heart using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded human liver damage using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse liver using MMP9 antibody at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse kidney using MMP9 antibody at dilution of 1:100 (40x lens).

Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways

JournalChinese Journal of Natural Medicines

ApplicationWB

IF3

SpeciesHuman

PMID
MicroRNA-133a inhibits cell proliferation, colony formation ability, migration and invasion by targeting matrix metallopeptidase 9 in hepatocellular carcinoma

JournalMolecular Medicine Reports

ApplicationWB

IF2.952

SpeciesHuman

PMID25607810
Holothurian glycosaminoglycan inhibits metastasis via inhibition of P-selectin in B16F10 melanoma cells

JournalMolecular And Cellular Biochemistry

ApplicationWB

IF2.795

SpeciesMouse

PMID26318439
Methylation of DACT2 Promotes Papillary Thyroid Cancer Metastasis by Activating Wnt Signaling

JournalPLoS One

ApplicationWB

IF2.776

SpeciesHuman

PMID25375359
Astrocyte elevated gene-1 promotes the proliferation and invasion of breast cancer cells by activating the Wnt/β‑catenin signaling pathway

JournalOncology Letters

ApplicationWB

IF2.311

SpeciesHuman

PMID28454408