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TLR4 (S441) polyclonal antibody（KU）

货号: BS3489

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3489

Product Name :TLR4 (S441) polyclonal antibody（KU）

Swiss-Prot :O00206

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF IP

Application_all :WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200

Background :Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti fungal response, while the related 18 wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TLR4 (S441) polyclonal antibody detects endogenous levels of TLR4 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Toll-like receptor 4; hToll; CD284; TLR-4

Immunogen :Synthetic peptide, corresponding to amino acids 421-470 of Human TLR4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TLR4 (S441) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:Myla2059 whole cell lysate(40ug) Lane4:Jurkat whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate (40ug)

Immunohistochemistry (IHC) analyzes of TLR4 (S441) pAb in paraffin-embedded human brain tissue.

Involvement of TLR4 in Oxidized LDL/β2GPI/Anti-β2GPI-Induced Transformation of Macrophages to Foam Cells

JournalJournal of Atherosclerosis and Thrombosis

ApplicationWB

IF3.478

SpeciesMouse

PMID24998486
Toll like receptor 4 facilitates invasion and migration as a cancer stem cell marker in hepatocellular carcinoma

JournalCancer Letters

ApplicationIHC,WB,IF

IF7.36

SpeciesHuman,Mouse

PMID25511737
The C-Terminal Disulfide Bonds of Helicobacter pylori GroES Are Critical for IL-8 Secretion via the TLR4-Dependent Pathway in Gastric Epithelial Cells

JournalJournal Of Immunology

ApplicationWB,ELISA

IF4.886

SpeciesHuman

PMID25769921
The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway

JournalMolecular And Cellular Endocrinology

ApplicationWB

IF3.693

SpeciesMouse

PMID25596549
Sinomenine down-regulates TLR4/TRAF6 expression and attenuates lipopolysaccharide-induced osteoclastogenesis and osteolysis

JournalEuropean Journal Of Pharmacology

ApplicationWB

IF3.263

SpeciesMouse

PMID26965104