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TLR4 (S441) polyclonal antibody（KU）

货号: BS3489

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3489

Product Name :TLR4 (S441) polyclonal antibody（KU）

Swiss-Prot :O00206

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF IP

Application_all :WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200

Background :Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti fungal response, while the related 18 wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TLR4 (S441) polyclonal antibody detects endogenous levels of TLR4 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Toll-like receptor 4; hToll; CD284; TLR-4

Immunogen :Synthetic peptide, corresponding to amino acids 421-470 of Human TLR4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TLR4 (S441) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:Myla2059 whole cell lysate(40ug) Lane4:Jurkat whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate (40ug)

Immunohistochemistry (IHC) analyzes of TLR4 (S441) pAb in paraffin-embedded human brain tissue.

Role of TREM-1 in the development of early brain injury after subarachnoid hemorrhage

JournalExperimental Neurology

ApplicationWB

IF4.691

SpeciesRat

PMID33727099
Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex

JournalCellular Signalling

ApplicationWB

IF3.968

SpeciesHuman

PMID33080316
Ethyl pyruvate enhances spontaneous remyelination by targeting microglia phagocytosis

JournalInternational Immunopharmacology

ApplicationIHC

IF3.943

SpeciesMouse

PMID31677497
Dynamic Balance of Microglia and Astrocytes Involved in the Remyelinating Effect of Ginkgolide B

JournalFrontiers in Cellular Neuroscience

ApplicationIHC

IF3.921

SpeciesMouse

PMID31969806
Melanin of Sporothrix globosa affects the function of THP-1 macrophages and modulates the expression of TLR2 and TLR4

JournalMicrobial Pathogenesis

ApplicationWB

IF3.738

SpeciesHuman

PMID34454025