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TLR4 (S441) polyclonal antibody（KU）

货号: BS3489

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3489

Product Name :TLR4 (S441) polyclonal antibody（KU）

Swiss-Prot :O00206

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF IP

Application_all :WB 1:500 - 1:2000 IHC 1:100 - 1:200 IF 1:50 - 1:200 IP 1:50 - 1:200

Background :Toll like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti fungal response, while the related 18 wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities have been implicated in the innate host defense to pathogens. TLR4 has been identified next to MD2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram negative bacteria.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TLR4 (S441) polyclonal antibody detects endogenous levels of TLR4 protein.

BiowMW :~ 120 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Toll-like receptor 4; hToll; CD284; TLR-4

Immunogen :Synthetic peptide, corresponding to amino acids 421-470 of Human TLR4.

Conjugate :Unconjugated

Modification :Unmodified

Western blot (WB) analysis of TLR4 (S441) pAb at 1:500 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:Myla2059 whole cell lysate(40ug) Lane4:Jurkat whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate (40ug)

Immunohistochemistry (IHC) analyzes of TLR4 (S441) pAb in paraffin-embedded human brain tissue.

Salvianolic acid A alleviated inflammatory response mediated by microglia through inhibiting the activation of TLR2/4 in acute cerebral ischemia-reperfusion

JournalPhytomedicine

ApplicationWB

IF5.34

SpeciesRat

PMID33985878
Curcumin improves memory deficits by inhibiting HMGB1-RAGE/TLR4-NF-κB signalling pathway in APPswe/PS1dE9 transgenic mice hippocampus

JournalJournal Of Cellular And Molecular Medicine

ApplicationWB

IF5.31

SpeciesMouse

PMID34405526
MyD88 determines the protective effects of fish oil and perilla oil against metabolic disorders and inflammation in adipose tissue from mice fed a high-fat diet

JournalNutrition & Diabetes

ApplicationWB

IF5.097

SpeciesMouse

PMID34168108
Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis

JournalInternational Immunopharmacology

ApplicationWB

IF4.932

SpeciesMouse

PMID30261464
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

JournalBiochemical Pharmacology

ApplicationWB

IF4.825

SpeciesMouse

PMID29753749