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CSNK2A2 monoclonal antibody

货号: MB21654

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21654

Product Name :CSNK2A2 monoclonal antibody

Swiss-Prot :P19784

Host :Mouse

Reactivity :Human,Mouse,Rat,Monkey,Rabbit

Applications :WB,IHC,FCM

Application_all :WB:1/500 - 1/2000 IHC:1/100 - 1/500 FC:1/200 - 1/400

Background :Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.

Product :Purified antibody in PBS with 0.05% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :41.2kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CK2A2; CSNK2A1; FLJ43934

Immunogen :Purified recombinant fragment of human CSNK2A2 (AA: 194-350) expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CSNK2A2 mouse mAb against HeLa (1), MCF-7 (2), HepG2 (3), Jurkat (4), NIH3T3 (5), and PC-12 (6) cell lysate.

Immunohistochemical analysis of paraffin-embedded Mouse kidney(A)Mouse kidney(B)Mouse cerebellum(C) using CSNK2A2 mouse mAb with DAB staining.

免疫沉淀（IP）

免疫组织化学（IHC）