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CRTC3 monoclonal antibody

货号: MB21435

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21435

Product Name :CRTC3 monoclonal antibody

Swiss-Prot :Q6UUV7

Host :Mouse

Reactivity :Human,Monkey

Applications :WB,IHC,IF

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Product :Ascitic fluid containing 0.03% sodium azide.

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :68kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :TORC3; FLJ21868; CRTC3

Immunogen :Purified recombinant fragment of human CRTC3 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using CRTC3 mouse mAb against Hela (1), Jurkat (2), Cos7 (3) and MCF-7 (4) cell lysate.

Immunohistochemical analysis of paraffin-embedded human breast cancer (left) and ovarian cancer (right) using CRTC3 mouse mAb with DAB staining.

Immunofluorescence analysis of NTERA-2 cells using CRTC3 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

免疫沉淀（IP）