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MCL-1 monoclonal antibody

货号: MB21043

价格：￥ 1200

货期：现货（1-2个工作日）

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No. :MB21043

Product Name :MCL-1 monoclonal antibody

Swiss-Prot :Q07820

Host :Mouse

Reactivity :Human

Applications :WB,IHC,IF

Application_all :WB:1/500 - 1/2000 IHC:1/200 - 1/1000 IF:1/200 - 1/1000

Background :Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that<br />increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or <br />exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related <br />protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This <br />monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.

Product :Purified antibody in PBS with 0.05% sodium azide

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mouse IgG1

BiowMW :37kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :EAT, MCL1L, MCL1S

Immunogen :Purified recombinant fragment of human MCL-1 expressed in E. Coli.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis using MCL1 mouse mAb against Hela (1), BCBL-1 (2), Jurkat (3) and HL60 (4) cell lysate.

Immunohistochemical analysis of paraffin-embedded human lymphnode tissues using MCL1 mouse mAb with DAB staining.

Confocal Immunofluorescence analysis of HepG2 cells using MCL1 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.