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FBXL18 polyclonal antibody

货号: BS9962M

价格：￥

货期：现货（1-2个工作日）

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No. :BS9962M

Product Name :FBXL18 polyclonal antibody

Swiss-Prot :Q96ME1

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IHC FC

Application_all :WB: 1:500 IHC: 1:50-1:200 FC: 1:50-1:100

Background :FBL18 (F-box and leucine-rich repeat protein 18), also known as FBXL18, is an 805 amino acid protein that contains an F-box near its N-terminus, followed by several leucine-rich repeats and a transmembrane domain at the C-terminus. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins and cyclin-dependent kinase inhibitors (CDKNs), for degradation by the proteasome after ubiquitination.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :Protein A affinity purified.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of FBXL18 and does not cross-react with related proteins.

BiowMW :~ 40, 88 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :F-box/LRR-repeat protein 18; F-box and leucine-rich repeat protein 18; FBXL18; FBL18

Immunogen :Synthetic peptide corresponding to human FBXL18 aa 750 to C terminus.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of FBXL18 on PC-3M cell lysate using anti-FBXL18 antibody at 1:500 dilution.

Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-FBXL18 antibody. Counter stained with hematoxylin.

Flow cytometric analysis of A549 cells with FBXL18 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.