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SMO polyclonal antibody

货号: BS70534

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70534

Product Name :SMO polyclonal antibody

Swiss-Prot :Q99835

Host :Rabbit

Reactivity :Human, Mouse, Rat

Applications :WB, IHC

Application_all :WB,1:500 - 1:1000|IHC,1:100 - 1:200

Background :The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SMO pAb detects endogenous levels of SMO protein.

BiowMW :~ 95 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Gx;CRJS;SMOH;FZD11;SMO

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SMO.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of SMO expression in HEK293T (A), HepG2 (B), H1688 (C), mouse liver (D), mouse muscle (E), rat liver (F), rat muscle (G) whole cell lysates.

Immunohistochemical analysis of SMO staining in human breast cancer formalin fixed paraffin embedded tissue section.

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

JournalMolecular Cancer

ApplicationWB

IF27.401

SpeciesHuamn

PMID
Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer

JournalClinical Cancer Research

ApplicationWB

IF12.531

SpeciesHuman

PMID24947933
SDF-1/CXCR4 signaling induces pancreatic cancer cell invasion and epithelial–mesenchymal transition in vitro through non-canonical activation of Hedgehog pathway

JournalCancer Letters

ApplicationWB

IF8.679

SpeciesHuman

PMID
Cyclosporin A impairs neurogenesis and cognitive abilities in brain development via the IFN-γ-Shh-BDNF pathway

JournalInternational Immunopharmacology

ApplicationWB

IF4.932

SpeciesMouse

PMID33993101
CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway

JournalOncology Reports

ApplicationWB

IF3.041

SpeciesHuman

PMID29115520