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Bax polyclonal antibody

货号: BS6420

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6420

Product Name :Bax polyclonal antibody

Swiss-Prot :Q07812

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC

Application_all :WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bax polyclonal antibody detects endogenous levels of Bax protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4

Immunogen :Recombinant full length Human Bax.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using BAX antibody at 1:1000 dilution. Lysates/proteins: 40ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 90s.

Immunohistochemistry of paraffin-embedded mouse testis using BAX antibody at dilution of 1:100 (40x lens).

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