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Bax polyclonal antibody

货号: BS6420

价格：￥ 1350

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS6420

Product Name :Bax polyclonal antibody

Swiss-Prot :Q07812

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IHC

Application_all :WB 1:2000 - 1:5000 IHC 1:50 - 1:200

Background :The Bcl-2 gene was isolated at the chromosomal breakpoint of t-bearing follicular B cell lymphomas. Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Bcl-2 is localized to outer mitochondrial membranes and endoplasmic reticulum as well as nuclear membranes. A related protein, designated Bax p21 (for Bcl-associated X protein), has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2. Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line, and Bax also counters the death repressor activity of Bcl-2.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Bax polyclonal antibody detects endogenous levels of Bax protein.

BiowMW :~ 20 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Regulation of Apoptosis,SAPK JNK Signaling Cascades,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,

Alternative Name :Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4; BAX; BCL2L4

Immunogen :Recombinant full length Human Bax.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using BAX antibody at 1:1000 dilution. Lysates/proteins: 40ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Exposure time: 90s.

Immunohistochemistry of paraffin-embedded mouse testis using BAX antibody at dilution of 1:100 (40x lens).

Immunoprecipitation - [KO Validated] Bax Rabbit pAb

Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice

JournalNeurochemical Research

ApplicationWB

IF3.038

SpeciesMouse

PMID28608237
Activation of cellular apoptosis in the caecal epithelium is associated with increased oxidative reactions in lactating goats after feeding a high-concentrate diet

JournalExperimental Physiology

ApplicationWB

IF2.969

SpeciesGoat

PMID25590230
Downregulation of angiogenin inhibits the growth and induces apoptosis in human bladder cancer cells through regulating AKT/mTOR signaling pathway

JournalJournal Of Molecular Histology

ApplicationWB,IHC

IF2.611

SpeciesHuman,Mouse

PMID25564356
CSE/H2S system protects mesenchymal stem cells from hypoxia and serum deprivation‑induced apoptosis via mitochondrial injury, endoplasmic reticulum stress and PI3K/Akt activation pathways

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesRat

PMID25901909
Promoting effects of IL‑23 on myocardial ischemia and reperfusion are associated with increased expression of IL‑17A and upregulation of the JAK2‑STAT3 signaling pathway

JournalMolecular Medicine Reports

ApplicationWB

IF1.851

SpeciesRat

PMID29039526