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CD200R1 polyclonal antibody

货号: BS61747

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS61747

Product Name :CD200R1 polyclonal antibody

Swiss-Prot :Q8TD46

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :OX2 (CD200, MOX2), a member of the immunoglobulin superfamily (IgSF), is a 248-residue cell surface glycoprotein that is expressed in lymphoid cells, neurons and endothelium. OX2 receptor (OX2R) is a membrane protein with up to 70% of its weight derived from N-linked glycosylation, and it is primarily expressed in lymphoid and neuronal tissue. Phylogenetic analysis of OX2R with respect to other leukocyte IgSF glycoproteins suggests that OXR2 and OX2 share a common ancestral protein. The cytoplasmic portion of OX2R contains NPXY motifs that are known to interact with PTB/PID binding domains. The interaction between OX2 and OX2R may contribute to pathways that suppress and limit macrophage induced inflammatory damage in tissue.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CD200R1 polyclonal antibody detects endogenous levels of CD200R1 protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1; CD200R1; CD200R; CRTR2; MOX2R; OX2R; UNQ2522; PRO6015

Immunogen :Synthetic peptide, corresponding to amino acids 250-300 of Human CD200R1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CD200R1 polyclonal antibody at 1:1000 dilution Lane1:L02 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:AML-12 whole cell lysate(40ug) Lane4:H9C2 whole cell lysate(40ug)

Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-κB signaling pathway in aged mice

JournalINFLAMMATION RESEARCH

ApplicationWB

IF6.7

SpeciesMouse

PMID37902837
Activation of the CD200/CD200R1 axis improves cognitive impairment by enhancing hippocampal neurogenesis via suppression of M1 microglial polarization and neuroinflammation in hypoxic-ischemic neonatal rats

JournalINTERNATIONAL IMMUNOPHARMACOLOGY

ApplicationWB

IF5.6

SpeciesRat

PMID38237226