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Cathepsin B (N217) polyclonal antibody（KU）

货号: BS3536

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3536

Product Name :Cathepsin B (N217) polyclonal antibody（KU）

Swiss-Prot :P07858

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The cathepsin family of proteolytic enzymes contains several diverse classes of proteases. The cysteine protease class comprises cathepsins B, L, H, K, S, and O. The aspartyl protease class is composed of cathepsins D and E. Cathepsin G is in the serine protease class. Most cathepsins are lysosomal and each is involved in cellular metabolism, participating in various events such as peptide biosynthesis and protein degradation. Cathepsin B is expressed in luminal epithelial cells, indicating that cathepsin B is a marker for secretory cell death.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Cathepsin B (N217) polyclonal antibody detects endogenous levels of Cathepsin B protein.

BiowMW :~ 36 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,

Alternative Name :Cathepsin B; APP secretase; APPS; Cathepsin B1; CTSB; CPSB

Immunogen :Synthetic peptide, corresponding to amino acids 181-230 of Human Cathepsin B.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Cathepsin B (N217) pAb at 1:2000 dilution Lane1:The Embryo tissue lysate of Mouse(40ug) Lane2:The Lung tissue lysate of Rat(40ug) Lane3:HCT116 whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Cathepsin B (N217) pAb in paraffin-embedded human brain tissue.

SERTAD1 Sensitizes Breast Cancer Cells to Doxorubicin and Promotes Lysosomal Protein Biosynthesis

JournalBiomedicines

ApplicationWB

IF6.081

SpeciesHuman

PMID35625886