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ATF4 (R239) polyclonal antibody

货号: BS1026

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS1026

Product Name :ATF4 (R239) polyclonal antibody

Swiss-Prot :P18848

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :ATF4 is a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain (referenced from Entrez gene).

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :ATF4 (R239) polyclonal antibody detects endogenous levels of ATF4 protein.

BiowMW :~ 49 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; TaxREB67; ATF4; CREB2; TXREB

Immunogen :Synthetic peptide, corresponding to amino acids 200-250 of Human ATF4.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of ATF4 pAb at 1:5000 dilution Lane1:EC9706 whole cell lysate(40ug) Lane2:C6 whole cell lysate(40ug) Lane3:A375 whole cell lysate(40ug) Lane4:3T3-L1 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of ATF4 (R239) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

JournalOncotarget

ApplicationWB

IF0

SpeciesHuman

PMID26625200
HIIT and MICT attenuate high-fat diet-induced hepatic lipid accumulation and ER stress via the PERK-ATF4-CHOP signaling pathway

JournalJournal Of Physiology And Biochemistry

ApplicationWB

IF4.158

SpeciesRat

PMID35315506
Blueberry extract attenuates DSS-induced inflammatory bowel disease in mice through inhibiting ER stress-mediated colonic apoptosis in mice

JournalFood & Function

ApplicationWB,IF

IF5.1

SpeciesMouse

PMID39225067