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Alpha-crystallin B monoclonal antibody

货号: MB66774

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB66774

Product Name :Alpha-crystallin B monoclonal antibody

Swiss-Prot :P02511

Host :Mouse

Reactivity :Human, Mouse, Rat

Applications :WB

Application_all :WB (1/500 - 1/1000)

Background :Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into a, b and g families, and the b- and g-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions.a-crystallins consist of three gene products, aA-, aB- and aC-crystallin, which are members of the small heat shock protein family (HSP 20). a-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, a-crystallins do not renature these proteins. Expression of aA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human aB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of aB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

Product :Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Purification&Purity :This antibody is purified through a protein G column.

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recognizes endogenous levels of Alpha-crystallin B protein.

BiowMW :~ 23 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CRYA2; Alpha-crystallin B chain; Alpha(B)-crystallin; Heat shock protein beta-5; HspB5; Renal carcinoma antigen NY-REN-27; Rosenthal fiber component

Immunogen :Recombinant fusion protein of human Alpha-crystallin B. The exact sequence is proprietary.

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of Alpha-crystallin B expression in U87 MG (A), MCF7 (B), mouse heart (C), skeletal muscle (D), rat skeletal muscle (E) whole cell lysates.