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NFE2L1 monoclonal antibody

货号: MB0168

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0168

Product Name :NFE2L1 monoclonal antibody

Swiss-Prot :Q14494

Host :Mouse

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000

Background :The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs). A family of NF-E2-related proteins, which are collectively known as the cap ‘n’ collar (CNC) family and include NFE2L1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, Jun B and Jun D) to activate gene expression, specifically the detoxifying enzyme NQO1.

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of NFE2L1 and does not cross-react with related proteins

BiowMW :Predicted band size:67KDa Observed band size:72KDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :AMPK Signaling Pathway,

Alternative Name :NFE2L1HBZ17; NFE2L1; TCF11; TCF-11; Transcription factor HBZ17; Transcription factor LCR-F1; Transcription factor 11; Locus control region-factor 1; NF-E2-related factor 1; NFE2-related factor 1; Nuclear factor erythroid 2-related factor 1

Immunogen :Recombinant full length Human NFE2L1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of NFE2L1 in Hela, K562, CEM&U2OS cell lysates using NFE2L1 antibody (1:1000 diluted) .