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PPP4C monoclonal antibody

货号: MB0060

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :MB0060

Product Name :PPP4C monoclonal antibody

Swiss-Prot :P60510

Host :Mouse

Reactivity :Human

Applications :WB IHC ICC

Application_all :WB: 1:1000 ICC: 1:50~200 IHC: 1:500

Background :Protein phosphatase 4C may be involved in microtubule organization. It binds 1 iron ion and 1 manganese ion per subunit. PP4 consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PP X subfamily.Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity)

Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :This antibody detects endogenous levels of PPP4C and does not cross-react with related proteins

BiowMW :Predicted band size:34KDa Observed band size:34KDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein phosphatase 4 catalytic subunit; PP4C; Pp4; Protein phosphatase X; PP-X; PPP4C; PPP4; PPX

Immunogen :Recombinant full length Human PPP4C.

Conjugate :Unconjugated

Modification :Unmodification

Western blot detection of Protein Phosphatase 4C antibody in Hela, 293&Jurkat cell lysates using Protein Phosphatase 4C antibody (1:1000 diluted) .

IHC of paraffin-embedded human breast cancer using anti-Protein Phosphatase 4C diluted 1/500-1/1000.

Immunocytochemistry of HeLa cells using anti- Protein Phosphatase 4C antibody diluted 1:200.

免疫沉淀（IP）