Product Name :RREB1 (E597) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:100~1:200
Background :RREB1 (Ras responsive element binding protein 1), also known as FINB, LZ321 or Zep-1, is a 1,687 amino acid protein that localizes to nuclear speckles and contains fifteen C2H2-type zinc fingers. Expressed in pancreas, heart, liver, placenta, lung, kidney and skeletal muscle, RREB1 functions as a transcription factor that binds to the Ras-responsive element (RRE) of target gene promotors, thereby inducing their transcription. In addition, RREB1 is thought to be involved in Raf/Ras-mediated cell differentiation, possibly by enhancing the expression of Calcitonin, a hormone that is produced by the thyroid gland and plays an essential role in maintaining blood calcium levels. Due to its involvement in cell differentiation events, RREB1 may be involved in Raf/Rasrelated tumor formation. Four isoforms of RREB1 exist due to alternative splicing.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :RREB1 (E597) polyclonal antibody detects endogenous levels of RREB1 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :FINB; Ras-responsive element-binding protein 1; RREB-1; Finger protein in nuclear bodies; Raf-responsive zinc finger protein LZ321; Zinc finger motif enhancer-binding protein 1; Zep-1
Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RREB1.
