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NLRP3 polyclonal antibody

货号: BS90948

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS90948

Product Name :NLRP3 polyclonal antibody

Swiss-Prot :Q96P20

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB ELISA IHC IF

Application_all :WB: 1:500-1:2000 ELISA: 1:5000-1:10000 IHC: 1:100-1:500 IF: 1:100-1:500

Background :Cryopyrin interacts selectively with apoptosis associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling and caspase-1 activation. The complex also inhibits TNFa induced activation and nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin and Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurologic cutaneous and articular syndrome (CINCA).

Product :0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity :NLRP3 polyclonal antibody detects endogenous levels of NLRP3 protein.

BiowMW :~ 114 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :LRR and PYD domains-containing protein 3; AGTAVPRL; AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like; Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; Caterpiller protein 1.1; CIAS 1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Muckle-Wells syndrome; MWS; NACHT; NACHT LRR and PYD containing protein 3; NALP 3; NALP3; NALP3_HUMAN; NLRP3; PYPAF 1; PYPAF1 antibody PYRIN containing APAF1 like protein 1; PYRIN-containing APAF1-like protein 1

Immunogen :KLH conjugated synthetic peptide derived from human Cryopyrin: 551-630/1036

Conjugate :Unconjugated

Modification :Unmodification

Sample: Lung (Rat) Lysate at 40 ug Colon carcinoma (Human) Lysate at 40 ug Primary: Anti-NALP3 at 1/300 dilution

Tissue/cell: Rat tracheal tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-Cryopyrin Polyclonal Antibody, Unconjugated 1:200, overnight at 4°C.

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ApplicationWB

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JournalTISSUE & CELL

ApplicationWB

IF2.6

SpeciesMouse

PMID37913602