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NNMT polyclonal antibody（KU）

货号: BS8344

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS8344

Product Name :NNMT polyclonal antibody（KU）

Swiss-Prot :P40261

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotin-amide and other pyridines. NNMT activity in the human liver has a bimodal frequency distribution, indicating that its enzyme activity may be modulated through a genetic polymorphism, which could have functional implications for individual differences in drug and xenobiotic toxicity. The gene that encodes human NNMT is approximately 16.5 kb in length, consists of three exons and two introns and maps to 11q23.2. NNMT isolated from the human liver was determined to be 969 nucleotides in length, with a 792 nucleotide open reading frame that encodes a 264 amino acid protein. The NNMT gene is presumed to be a significant genetic determinant of plasma homocysteine levels in Spanish families, since it encodes an enzyme involved in homocysteine synthesis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :NNMT polyclonal antibody detects endogenous levels of NNMT protein.

BiowMW :~ 29 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Nicotinamide N-methyltransferase; NNMT

Immunogen :Recombinant full length Human NNMT.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of NNMT pAb at 1:1000 dilution Lane1:The liver tissue lysate of Mouse(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:SK-OVCAR3 whole cell lysate(40ug)

Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Biomarkers of Kidney Cancer

JournalProteomics Clinical Applications

ApplicationWB,IHC

IF3.494

SpeciesHuman

PMID28975715