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POMC polyclonal antibody

货号: BS7477
价格 1140
货期 现货(1-2个工作日)
25ul 50ul 100ul 200ul
No. :BS7477
Product Name :POMC polyclonal antibody
Swiss-Prot :P01189
Host :Rabbit
Reactivity :Human, Rat
Applications :IF/ICC
Application_all :IF/ICC,1:50 - 1:200
Background :This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
Product :1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Polyclonal Antibodies
BiowMW :Refer to figures
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :POMC;ACTH;CLIP;LPH;MSH;NPP;POC
Immunogen :A synthetic peptide of human POMC(NP_000930.1).
Conjugate :Unconjugated
Modification :Unmodification
Immunofluorescence analysis of HeLa cells using POMC Rabbit pAb at dilution of 1:200 . Blue: DAPI for nuclear staining.
Immunofluorescence analysis of PC-12 cells using POMC Rabbit pAb at dilution of 1:200 . Blue: DAPI for nuclear staining.
  • Exogenous Melatonin Regulates Puberty and the Hypothalamic GnRH-GnIH System in Female Mice
    JournalBrain Sciences
    ApplicationWB
    IF3.333
    SpeciesMouse

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400-660-9091

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com