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RANKL polyclonal antibody

货号: BS72037

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS72037

Product Name :RANKL polyclonal antibody

Swiss-Prot :O14788

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB,IF/ICC,ELISA

Application_all :WB 1:500 - 1:1000; IF 1:50 - 1:200

Background :This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human RANKL

BiowMW :~ 32 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :CD254; ODF; OPGL; OPTB2; RANKL; TNLG6B; TRANCE; hRANKL2; sOdf

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 78-317 of human RANKL

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using RANKL antibody at 1:1000 dilution.

Immunohistochemistry of paraffin-embedded human colon using RANKL Antibody at dilution of 1:100 (40x lens).

Immunofluorescence analysis of Jurkat cells using RANKL antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

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