产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

α-SMA polyclonal antibody（KU）

货号: BS70000

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70000

Product Name :α-SMA polyclonal antibody（KU）

Swiss-Prot :P62736

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :α-SMA polyclonal antibody detects endogenous levels of α-SMA protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ACTA2; AAT6; ACTSA; MYMY5; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; alpha-SMA; a-SMA; aSMA; SMA-alpha

Immunogen :Synthetic peptide, corresponding to Human α-SMA.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of α-SMA pAb at 1:1000 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug)

Smad3-related miRNAs regulated oncogenic TRIB2 promoter activity to effectively suppress lung adenocarcinoma growth

JournalCell Death & Disease

ApplicationWB,IF

IF5.959

SpeciesHuman

PMID28005074
Neotuberostemonine attenuates bleomycin-induced pulmonary fibrosis by suppressing the recruitment and activation of macrophages

JournalInternational Immunopharmacology

ApplicationWB

IF4.932

SpeciesMouse

PMID27144994
Positive Feedback Regulation between Transglutaminase 2 and Toll-Like Receptor 4 Signaling in Hepatic Stellate Cells Correlates with Liver Fibrosis Post Schistosoma japonicum Infection

JournalFrontiers in Immunology

ApplicationIHC,IF,WB

IF4.716

SpeciesMouse,Human

PMID29321784
Sulindac has strong antifibrotic effects by suppressing STAT3‐related miR‐21

JournalJournal Of Cellular And Molecular Medicine

ApplicationWB,IF

IF4.658

SpeciesRat

PMID25704671
Qiliqiangxin inhibits angiotensin II‐induced transdifferentiation of rat cardiac fibroblasts through suppressing interleukin‐6

JournalJournal Of Cellular And Molecular Medicine

ApplicationWB,IF

IF4.658

SpeciesRat

PMID25752645