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α-SMA polyclonal antibody（KU）

货号: BS70000

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS70000

Product Name :α-SMA polyclonal antibody（KU）

Swiss-Prot :P62736

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB: 1:1000~1:2000

Background :Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :α-SMA polyclonal antibody detects endogenous levels of α-SMA protein.

BiowMW :~ 45 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :ACTA2; AAT6; ACTSA; MYMY5; Actin, aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein; alpha-SMA; a-SMA; aSMA; SMA-alpha

Immunogen :Synthetic peptide, corresponding to Human α-SMA.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of α-SMA pAb at 1:1000 dilution Lane1:MCF-7 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug)

Hemin attenuates bleomycin-induced lung fibrosis in mice by regulating the TGF-β1/MAPK and AMPK/SIRT1/PGC-1α/HO-1/NF-κB pathways

Journal10.4196/kjpp.2024.28.6.559

ApplicationIHC

IF1.6

SpeciesMouse

PMID39467719