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MEF2A (Acetyl-K403) polyclonal antibody

货号: BS64105

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64105

Product Name :MEF2A (Acetyl-K403) polyclonal antibody

Swiss-Prot :Q02078

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :MEF2A is a member of the MEF2 (myocyte enhancer factor 2) family of transcription factors. In mammals, four MEF2A-related genes (MEF2A, MEF2B, MEF2C and MEF2D) encode proteins which exhibit significant amino acid sequence similarity within their DNA binding domains and to a lesser extent throughout the remaining proteins. The MEF2 family members were originally described as muscle-specific DNA binding proteins that recognize MEF2 motifs found within the promoters of many muscle-specific genes. Phosphorylation of MEF2A at Thr312 and Thr319 within the transcription activation domain by p38 MAP kinase enhances MEF2A-MEF2D heterodimer-dependent gene expression. On the other hand, apoptotic stimuli (e.g. neurotoxic insult) result in CDK5-dependent phosphorylation of MEF2A at Ser408 within the activation domain, inhibiting MEF2A pro-survival function.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :MEF2A (Acetyl- -K403) polyclonal antibody detects endogenous levels of MEF-2 protein only when acetylated at Lys403.

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Signaling Pathways Activating p38 MAP Kinase,Examples of Crosstalk Between Post-translational Modifications,

Alternative Name :Myocyte-specific enhancer factor 2A; Serum response factor-like protein 1; MEF2A; MEF2

Immunogen :Synthetic Acetylated peptide derived from human MEF2A around the acetylation site of lysine 403.

Conjugate :Unconjugated

Modification :Acetylated

Western blot (WB) analysis of MEF2A (Acetyl-K403) polyclonal antibody at 1:500 dilution Lane1:The muscle tissue lysate of Mouse(30ug) Lane2:The muscle tissue lysate of Rat(30ug) Lane3:The brain tissue lysate of Mouse(30ug) Lane4:The brain tissue lysate of Rat(30ug) Lane5:HEK293T whole cell lysate(40ug)

Identification of the crucial molecular events during the large-scale myoblast fusion in sheep

JournalPhysiological Genomics

ApplicationWB

IF3.107

SpeciesSheep

PMID24790084