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TLK1 (phospho-S743) polyclonal antibody

货号: BS64008

价格：￥ 1350

货期：现货（1-2个工作日）

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No. :BS64008

Product Name :TLK1 (phospho-S743) polyclonal antibody

Swiss-Prot :Q9UKI8

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :The Tousled-like kinases (TLK1 and TLK2, also designated PKU-β and PKU-α, respectively) are the human homologs of the Tousled gene from Arabidopsis thaliana, which encodes a Serine/Threonine kinase that is necessary for proper organ morphogenesis. Both TLKs contain a nuclear localization signal and a predicted coiled-coil region in the N-terminal domain. TLK is ubiquitously expressed, and is prevalent in mouse testis, especially in pachytene spermatocytes and round spermatids. It displays a propensity to dimerize through an interaction between its coiled-coil structure and is able to autophosphorylate, as well as phosphorylate exogenous substrates. TLK1 and TLK2 are regulated by the cell cycle, showing maximum activity during S phase. Subsequently, they are thought to regulate the development of multicellular organisms, including playing a key role in spermatogenesis, through a series of phosphorylations.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-TLK1 (S743) polyclonal antibody detects endogenous levels of TLK1 protein only when phosphorylated at Ser743.

BiowMW :~ 86 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Serine/threonine-protein kinase tousled-like 1 ; PKU-beta; Tousled-like kinase 1; TLK-1; KIAA0137; PKU-β; PKU β; PKUβ

Immunogen :Synthetic phosphopeptide derived from human TLK1 around the phosphorylation site of Serine 743.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-TLK1 (S743) polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate Lane2:Rat brain tissue lysate Lane3:H9C2 whole cell lysate