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Claudin 19 polyclonal antibody

货号: BS62338

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS62338

Product Name :Claudin 19 polyclonal antibody

Swiss-Prot :Q8N6F1

Host :Rabbit

Reactivity :Human

Applications :WB

Application_all :WB:1:500~1:1000

Background :The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-19 is a 224 amino acid multi-pass membrane protein that belongs to the claudin family and is expressed as two isoforms due to alternative splicing events. Defects in the gene encoding claudin-19 are the cause of hypomagnesemia renal with ocular involvement (HOMGO), a renal disease characterized by hypomagnesemia, hypercalciuria and nephrocalcinosis.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Claudin 19 polyclonal antibody detects endogenous levels of Claudin 19 protein.

BiowMW :~ 21 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Claudin-19; CLDN19

Immunogen :Synthetic peptide, corresponding to Human Claudin 19.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Claudin 19 polyclonal antibody at 1:500 dilution LaneA:L02 whole cell lysate LaneB:HEK293T whole cell lysate LaneC:A549 whole cell lysate