Product Name :STEAP2 polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :STEAP2 (six transmembrane epithelial antigen of the prostate 2), also known as STMP, IPCA1, PUMPCn, STAMP1 or PCANAP1, is a 490 amino acid multi-pass membrane protein that localizes to the cell membrane and the endosomal membrane, as well as to the Golgi and to vesicular tubular structures in the cytosol. Highly expressed in prostate and present at lower levels in kidney, heart, ovary, brain and pancreas, STEAP2 contains one ferric oxidoreductase domain and, using FAD as a cofactor, functions as a metalloreductase that is able to reduce both Cu(2+) and Fe(3+) to Cu(1+) and Fe(2+), respectively, thereby playing a role in iron and copper metabolism. Overexpression of STEAP2 is associated with the progression of prostate cancer, suggesting a role for STEAP2 in tumorigenesis. Multiple isoforms of STEAP2 exist due to alternative splicing events.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :STEAP2 polyclonal antibody detects endogenous levels of STEAP2 protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Metalloreductase STEAP2; Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1; STEAP2; PCANAP1, STAMP1; UNQ6507/PRO23203
Immunogen :Synthetic peptide, corresponding to amino acids 440-485 of Human STEAP2.
Modification :Unmodification
