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PRL polyclonal antibody

货号: BS60888

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60888

Product Name :PRL polyclonal antibody

Swiss-Prot :P01236

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Protein tyrosine phosphatases (PTPs) play a role in regulating diverse cellular processes. They form a small class of prenylated protein phosphatases called PRL proteins characterized by a C-terminal consensus sequence for prenylation. PRL-1, also designated Protein tyrosine phosphatase type IVA protein 1 (PTP4A1), is a unique nuclear PTP that is induced in regenerating liver and mitogen-stimulated cells. It is primarily expressed in spleen, bone marrow, thymus, lymph nodes, T lymphocytes and tonsil and is overexpressed in tumor cell lines. PRL-2 (Protein tyrosine phosphatase type IVA protein 2, or PTP4A2) is ubiquitously expressed with highest levels in heart, skeletal muscle and thymus but is also overexpressed in prostate tumor tissue. PPRL-2 is stimulates progression from G1 into S phase during mitosis and promotes tumors. PRL-3, also known as Protein Tyrosine Phosphatase Type IVA, member 3 (PTP4A3) is expressed in heart and skeletal muscle as well as epithelial cells of the small intestine and associates with the cell plasma membrane. Over expression of PRL-3 inhibits angiotensin-II induced cell calcium mobilization and promotes cell growth. PRL-3 is important for colorectal cancer metastasis and may serve as a new therapeutic target for this condition.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PRL polyclonal antibody detects endogenous levels of PRL protein.

BiowMW :~ 26 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Prolactin; PRL; PRL

Immunogen :A synthetic peptide corresponding to residues in Human PRL.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PRL polyclonal antibody at 1:500 dilution Lane1:A549 whole cell lysate Lane2:MCF-7 whole cell lysate Lane3:H9C2 whole cell lysate Lane4:SP20 whole cell lysate