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CSF3 polyclonal antibody

货号: BS60536

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS60536

Product Name :CSF3 polyclonal antibody

Swiss-Prot :P09919

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB

Application_all :WB: 1:500~1:1000

Background :Granulocyte-colony stimulating factor, G-CSF, is a pleiotropic cytokine that influences differentiation, proliferation and activation of the neutrophilic granulocyte lineage. The murine G-CSF cDNA encodes a 208 amino acid precursor containing a 30 amino acid signal peptide that is proteolytically cleaved to form a 178 amino acid residue mature protein. Two G-CSF cDNAs, which are identical except for a three amino acid deletion in the N-terminus of one form of the protein, have been isolated from human cells. Murine and human G-CSF share 73% sequence identity at the amino acid level. G-CSF signals through the G-CSF receptor, G-CSFR, a heavily glycosylated 812 amino acid polypeptide with a single transmembrane domain. Stimulation of the G-CSFR results in the activation of the Ras/MAPK pathway and phosphorylation of the adaptor protein Shc. Studies indicate that the kinases Lyn and Syk and the transcription factor Stat3 are activated in response to G-CSF stimulation.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CSF3 polyclonal antibody detects endogenous levels of CSF3 protein.

BiowMW :~ 22 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Granulocyte colony-stimulating factor; G-CSF; Pluripoietin; INN: Filgrastim; INN: Lenograstim; CSF3; C17orf33; GCSF

Immunogen :A synthetic peptide corresponding to residues in Human CSF3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of CSF3 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:Raw264.7 whole cell lysate Lane3:PC12 whole cell lysate