Product Name :MYL9 (phospho-S19) polyclonal antibody
Swiss-Prot :P24844/P19105
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
Background :Myosin regulatory light chains, including MRCL3 (also known as MRLC3 or MLCB), MRLC2 (also known as MLC-B) and MYL9 (also known as LC20, MLC2, MRLC1 or MYRL2), regulate contraction in smooth muscle and non-muscle cells via phosphorylation by myosin light chain kinase (MLCK). Phosphorylation of myosin regulatory light chains, catalyzed by MLCK in the presence of calcium and calmodulin, increases the Actin-activated myosin ATPase activity, thereby regulating the contractile activity. Myosin light chain is also located in striated skeletal muscle, where its function remains undefined.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p-MYL9 (S19) polyclonal antibody detects endogenous levels of MYL9 protein only when phosphorylated at Ser19. This antibody may detects endogenous levels of MYL12A protein only when phosphorylated at Ser18.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Myosin regulatory light polypeptide 9; 20 kDa myosin light chain; Short name=LC20; MLC-2C; Myosin RLC; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; MLC2; MRLC1; MYRL2; Myosin regulatory light chain 12A; MLC-2B; Myosin RLC; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain MRLC3; MYL12A; MLCB; MRLC3; RLC
Immunogen :Synthetic phosphopeptide derived from human MYL9 around the phosphorylation site of Serine 19.
Modification :Phosphorylation
