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Insulin Receptor (phospho-Y1355) polyclonal antibody（KU）

货号: BS4270

价格：￥ 1350

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS4270

Product Name :Insulin Receptor (phospho-Y1355) polyclonal antibody（KU）

Swiss-Prot :P06213

Host :Rabbit

Reactivity :Human

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :p-Insulin Receptor (Y1355) polyclonal antibody detects endogenous levels of Insulin Receptor protein only when phosphorylated at Tyr1355.

BiowMW :~ 156 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Insulin &Glucose Signaling,

Alternative Name :Insulin receptor; IR; CD220; INSR

Immunogen :Synthetic phosphopeptide derived from human Insulin Receptor around the phosphorylation site of Tyrosine 1355.

Conjugate :Unconjugated

Modification :Phosphorylation

Western blot (WB) analysis of p-Insulin Receptor (Y1355) pAb at 1:500 dilution Lane1:H1792 whole cell lysate(40ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of p-Insulin Receptor (Y1355) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Insulin signaling disruption in male mice due to perinatal bisphenol A exposure: Role of insulin signaling in the brain

JournalToxicology Letters

ApplicationWB

IF3.499

SpeciesMouse

PMID26779933
Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line

JournalJournal Of Toxicological Sciences

ApplicationWB

IF1.737

SpeciesHuman

PMID31270305