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Integrin β3 (S778) polyclonal antibody（KU）

货号: BS3660

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS3660

Product Name :Integrin β3 (S778) polyclonal antibody（KU）

Swiss-Prot :P05106

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Integrin β3 (S778) polyclonal antibody detects endogenous levels of Integrin β3 protein.

BiowMW :~ 87, 110 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,Contribution of ECM and Cytoskeletal Factors to EMT,

Alternative Name :Integrin beta-3; Platelet membrane glycoprotein IIIa; Short name=GPIIIa; CD_antigen=CD61; ITGB3; GP3A; CD61; GPIIIa;

Immunogen :Synthetic peptide, corresponding to amino acids 751-800 of Human Integrin β3.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Integrin β3 (S778) pAb at 1:500 dilution Lane1:BV2 whole cell lysate(40ug) Lane2:RAW264.7 whole cell lysate(40ug) Lane3:The Uterus tissue lysate of Rat(40ug) Lane4:THP-1 whole cell lysate(40ug) Lane5:A549 whole cell lysate(40ug) Lane6:PC3 whole cell lysate(40ug) Lane7:U-87MG whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Integrin β3 (S778) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

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