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Lamin B1 (L75) polyclonal antibody（KU）

货号: BS3547

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS3547

Product Name :Lamin B1 (L75) polyclonal antibody（KU）

Swiss-Prot :P20700

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :An important part of the nucleus is formed by nuclear lamina. Nuclear lamins form a network of filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. The nuclear lamins comprise a unique subclass of the intermediate filament protein family. They share a molecular domain organisation with the other intermediate filament proteins in that they are fibrous molecules that have an aminoterminal globular head, a central rod of alpha helices and a carboxy terminal globular domain. Many biochemical and molecular features of lamins have been studied, but their functions remain still largely undetermined. One of the functions ascribed to the lamina is the maintenance of the structural integrity of the nucleus.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Lamin B1 (L75) polyclonal antibody detects endogenous levels of Lamin B1 protein.

BiowMW :~ 68 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Lamin-B1; LMNB1; LMN2; LMNB

Immunogen :Synthetic peptide, corresponding to amino acids 50-100 of Human Lamin B1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Lamin B1 (L75) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(20ug) Lane2:H1792 whole cell lysate(20ug) Lane3:The Kidney tissue lysate of Rat(40ug) Lane4:The Kidney tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of Lamin B1 (L75) pAb in paraffin-embedded human brain tissue.

Metabotropic glutamate receptor 5 promotes blood-brain barrier recovery after traumatic brain injury

JournalEXPERIMENTAL NEUROLOGY

ApplicationWB

IF5.3

SpeciesMouse

PMID38224942