Product Name :TAT (E304) polyclonal antibody
Reactivity :Human,Mouse,Rat
Application_all :IHC:1:50~1:200
Background :TAT (tyrosine aminotransferase) is a 454 amino acid protein that localizes to mitochondria and belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Existing as a homodimer, TAT uses pyridoxal phosphate as a cofactor to catalyze the conversion of L-tyrosine into p-hydroxyphenylpyruvate, a reaction that is important in amino acid degradation. Defects in the gene encoding TAT are the cause of tyrosinemia type 2 (TYRO2), an inborn error of metabolism that is associated with elevated levels of tyrosine in blood and urine and is characterized by palmoplantar keratosis, painful corneal ulcers and mental retardation. The gene encoding TAT maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :TAT (E304) polyclonal antibody detects endogenous levels of TAT protein.
Note :For research use only, not for use in diagnostic procedure.
Alternative Name :Tyrosine aminotransferase; TAT; L-tyrosine:2-oxoglutarate aminotransferase
Immunogen :Synthetic peptide, corresponding to amino acids 270-320 of Human TAT.
Modification :Unmodification
