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IL-1β (F162) polyclonal antibody

货号: BS3506

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS3506

Product Name :IL-1β (F162) polyclonal antibody

Swiss-Prot :P01584

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:100~1:200

Background :Two forms of interleukin-1, designated IL-1α and IL-1β, have been described. Although encoded by distinct genes and exhibiting roughly only 25% sequence identity, IL-1α and IL-1β bind to the same receptor and seem to elicit similar biological responses. IL-1 production is generally thought to be associated with inflammation, but it has also been shown to be expressed during kidney development, thymocyte differentiation and cartilage degradation. IL-1 plays a critical role in the regulation of immune response and inflammation, acting as an activator of T and B lymphocytes and natural killer (NK) cells.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :IL-1β (F162) polyclonal antibody detects endogenous levels of IL-1β protein.

BiowMW :~ 43, 35, 17 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Immune Cell Signaling,Inflammasonme Signaling,Necrotic Cell Death,

Alternative Name :Interleukin-1 beta; IL-1 beta; Catabolin; IL1B; IL1F2; IL-1β; IL1β

Immunogen :KLH-conjugated synthetic peptide encompassing a sequence within the center region of human IL-1 beta.

Conjugate :Unconjugated

Modification :Unmodified

Western blot analysis of IL-1β expression in Raw264.7 (A), mouse spleen (B), rat spleen (C), rat thymus (D), mouse thymus (E), Jurkat (F), THP1 (G) whole cell lysates.

Immunohistochemical analysis of IL-1β staining in human lung cancer formalin fixed paraffin embedded tissue section.

Clemastine improves hypomyelination in rats with hypoxic–ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway

JournalJournal of Neuroinflammation

ApplicationWB

IF5.793

SpeciesRat

PMID32061255
Systematic understanding of the mechanism and effects of Arctigenin attenuates inflammation in dextran sulfate sodium-induced acute colitis through suppression of NLRP3 inflammasome by SIRT1

JournalAmerican Journal of Translational Research

ApplicationWB

IF4.06

SpeciesMouse

PMID31396314
Using Network Pharmacology for Systematic Understanding of Geniposide in Ameliorating Inflammatory Responses in Colitis Through Suppression of NLRP3 Inflammasome in Macrophage by AMPK/Sirt1 Dependent Signaling

JournalAmerican Journal Of Chinese Medicine

ApplicationWB

IF3.682

SpeciesMouse

PMID33202149
Avenanthramide C from Oats Protects Pyroptosis through Dependent ROS-Induced Mitochondrial Damage by PI3K Ubiquitination and Phosphorylation in Pediatric Pneumonia

JournalJournal Of Agricultural And Food Chemistry

ApplicationWB

IF5.279

SpeciesMouse

PMID35119859
Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation <i>via</i> an Adenosine-5'-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice.

JournalFrontiers in Pharmacology

ApplicationWB

IF5.81

SpeciesMouse

PMID35370693