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CRF (R153) polyclonal antibody

货号: BS2869

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2869

Product Name :CRF (R153) polyclonal antibody

Swiss-Prot :P06850

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :IHC

Application_all :IHC: 1:50~1:200

Background :Individuals suffering from Alzheimer’s disease (AD) exhibit dramatic reductions in the content of corticotropin-releasing factor (CRF), increased expression of CRF receptors (CRFRs) and abnormalities in neuronal morphology in affected brain areas. In addition, AD patients show decreased concentrations of CRF in their cerebrospinal fluid, which may contribute to their cognitive impairment. A high affinity CRF binding protein, designated CRF-BP, has been discovered in post-mortem brain samples from AD patients. CRF-BP serves to bind and inactivate CRF, reducing the pool of “free CRF” available to bind CRFRs. Two CRFRs, designated CRF-RI and CFR-RII, have been described and exhibit distinct brain localizations.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :CRF (R153) polyclonal antibody detects endogenous levels of CRF protein.

BiowMW :~ 21 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Corticoliberin; Corticotropin-releasing factor; CRF; Corticotropin-releasing hormone; CRH

Immunogen :Synthetic peptide, corresponding to amino acids 121-170 of Human CRF.

Conjugate :Unconjugated

Modification :Unmodification

Immunohistochemistry (IHC) analyzes of CRF (R153) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer’s disease-like tau hyperphosphorylation

JournalEnvironmental Health and Preventive Medicine

ApplicationWB

IF3.674

SpeciesRat

PMID29228900
Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid

JournalJournal Of Alzheimers Disease

ApplicationWB

IF3.517

SpeciesMouse

PMID26577520
Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus

JournalJournal Of Neurochemistry

ApplicationWB

IF5.372

SpeciesMouse

PMID32096869