Product Name :Cofilin1/2 (T88) polyclonal antibody
Swiss-Prot :Q9Y281/P23528
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IF: 1:50~1:200
Background :Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin,thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors such as opsonized zymosan.Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :Cofilin1/2 (T88) polyclonal antibody detects endogenous levels of Cofilin1/2 protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Phosphoinosotode Signaling,Regulation of Actin Dynamics,Tumor Angiogenesis,Regulation of Microtubule Dynamics,
Alternative Name :Cofilin-1; Cofilin1; Cofilin 1; 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform; CFL1; CFL; Cofilin-2; Cofilin2; Cofilin 2; Cofilin, muscle isoform; CFL2
Immunogen :Synthetic peptide, corresponding to amino acids 55-100 of Human Cofilin1.
Modification :Unmodification
