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Mnk1 (I136) polyclonal antibody

货号: BS2133

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS2133

Product Name :Mnk1 (I136) polyclonal antibody

Swiss-Prot :Q9BUB5

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB:1:500~1:1000 IHC: 1:50~1:200

Background :The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK). The serine/threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Mnk1 (I136) polyclonal antibody detects endogenous levels of Mnk1 protein.

BiowMW :~ 51 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Phospholipase Signaling,Translational Contral elF4 and p70 S6 Kinase,Signaling Pathways Activating p38 MAP Kinase

Alternative Name :MAP kinase-interacting serine/threonine-protein kinase 1; MAP kinase signal-integrating kinase 1; Mnk1; MKNK1; MNK1;

Immunogen :Synthetic peptide, corresponding to amino acids 102-154 of Human Mnk1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Mnk1 pAb at 1:500 dilution Lane1:HEK293 whole cell lysate(40ug) Lane2:Hela whole cell lysate(40ug) Lane3:H446 whole cell lysate(40ug)