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Treacle (Q55) polyclonal antibody（KU）

货号: BS2047

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :BS2047

Product Name :Treacle (Q55) polyclonal antibody（KU）

Swiss-Prot :Q13428

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene. Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport. The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain. Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development. Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :Treacle (Q55) polyclonal antibody detects endogenous levels of Treacle protein.

BiowMW :~ 152 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Treacle protein; Treacher Collins syndrome protein; TCOF1

Immunogen :Synthetic peptide, corresponding to amino acids 22-73 of Human Treacle.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Treacle (Q55) pAb at 1:500 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:PC3 whole cell lysate(40ug) Lane3:A549 whole cell lysate(40ug) Lane4:PC12 whole cell lysate(40ug) Lane5:AML-12 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Treacle (Q55) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.