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PPAR-γ (I106) polyclonal antibody（KU）

货号: BS1587

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1587

Product Name :PPAR-γ (I106) polyclonal antibody（KU）

Swiss-Prot :P37231

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PPAR-γ (I106) polyclonal antibody detects endogenous levels of PPAR-γ protein .

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,MTOR signaling,

Alternative Name :Peroxisome proliferator-activated receptor gamma; Short name=PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG; NR1C3; PPAR γ; PPARγ

Immunogen :Synthetic peptide, corresponding to amino acids 90-120 of Human PPAR-γ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PPAR-γ (I106) polyclonal antibody at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of PPAR-γ (I106) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

PDGFR-β (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo

JournalInternational Journal of Clinical and Experimental Pathology

ApplicationIF

IF0.252

SpeciesH

PMID25031705
Pomegranate peel polyphenols inhibit lipid accumulation and enhance cholesterol efflux in raw264.7 macrophages

JournalFood & Function

ApplicationWB

IF5.396

SpeciesHuman

PMID27334099
The adipogenesis in infantile hemangioma and the expression of adipogenic-related genes

JournalInternational Journal of Clinical and Experimental Pathology

ApplicationIF

IF0.252

SpeciesHuman

PMID31966516
ACAT2 Is a Novel Negative Regulator of Pig Intramuscular Preadipocytes Differentiation

JournalBiomolecules

ApplicationWB

IF4.879

SpeciesPig

PMID
Exploring the Pattern of Metabolic Alterations Causing Energy Imbalance via PPARα Dysregulation in Cardiac Muscle During Doxorubicin Treatment

JournalCardiovascular Toxicology

ApplicationIHC

IF3.231

SpeciesRat

PMID