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PPAR-γ (I106) polyclonal antibody（KU）

货号: BS1587

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1587

Product Name :PPAR-γ (I106) polyclonal antibody（KU）

Swiss-Prot :P37231

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :PPAR gamma is implicated in numerous diseases including obesity, diabetes, atherosclerosis and cancer. PPAR gamma activators include prostanoids, fatty acids, thiazolidinediones and N-(2-benzoylphenyl) tyrosine analogues. A key component in adipocyte differentiation and fat-specific gene expression, PPAR gamma may modulate macrophage functions such as proinflammatory activities, and stimulate oxidized low-density lipoprotein (x-LDL) uptake. A Pro12Ala polymorphism of the PPAR gamma2 gene has been reported to reduce transactivation activity in vitro. This substitution may affect the immune response to ox-LDL and be associated with type 2 diabetes. In addition, the Pro12Ala variant of the PPAR gamma2 gene maybe correlated with abdominal obesity in type 2 diabetes.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :PPAR-γ (I106) polyclonal antibody detects endogenous levels of PPAR-γ protein .

BiowMW :~ 54 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Nuclear Receptor Signaling,MTOR signaling,

Alternative Name :Peroxisome proliferator-activated receptor gamma; Short name=PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG; NR1C3; PPAR γ; PPARγ

Immunogen :Synthetic peptide, corresponding to amino acids 90-120 of Human PPAR-γ.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of PPAR-γ (I106) polyclonal antibody at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:PC12 whole cell lysate(40ug) Lane4:L02 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of PPAR-γ (I106) pAb in paraffin-embedded human tonsil carcinoma tissue at 1:50.

Pomegranate punicalagin inhibits the foam cells formation in Raw264.7 macrophages

JournalFood Science and Technology

ApplicationWB

IF2.602

SpeciesMouse

PMID