产品类别

联系我们

电话:025-68037686

地址:江苏生命科技创新园F6幢1层

订购:nanjing03@biogot.com

服务:biorase01@biogot.com

合作:lvyun@biogot.com

支持:may@biogot.com

SENP1 (D2) polyclonal antibody（KU）

货号: BS1469

价格：￥ 1140

货期：现货（1-2个工作日）

25ul 50ul 100ul 200ul

抗体定制服务咨询

说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1469

Product Name :SENP1 (D2) polyclonal antibody（KU）

Swiss-Prot :Q9P0U3

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200

Background :SUMO (small ubiquitin-related modifier), a member of the ubiquitin-like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO-specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin-specific (or SUMO-specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1-3 and SENP5-8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SENP1 (D2) polyclonal antibody detects endogenous levels of SENP1 protein.

BiowMW :~ 73 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1; SEN1

Immunogen :Synthetic peptide, corresponding to the N-terminual of Human SENP1.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of SENP1 (D2) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:The Testis cells tissue lysate of Rat(40ug) Lane3:The Testis cells tissue lysate of Mouse(40ug)

Immunohistochemistry (IHC) analyzes of SENP1 (D2) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

SENP1 inhibits the IH-induced apoptosis and nitric oxide production in BV2 microglial cells

JournalBiochemical And Biophysical Research Communications

ApplicationWB

IF2.705

SpeciesMouse

PMID26499079