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TIMP-2 (A47) polyclonal antibody（KU）

货号: BS1366

价格：￥ 1140

货期：现货（1-2个工作日）

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说明书 MSDS SHIP

详细信息检测数据实验指南文献

No. :BS1366

Product Name :TIMP-2 (A47) polyclonal antibody（KU）

Swiss-Prot :P16035

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases 1, 2, 3 and 4) complex with metalloproteinases such as collagenases, gelatin-ases and stromelysins, resulting in irreversible inactivation of the metallopro-teinase. TIMP-1 has been found to be identical to EPA (erythroid-potentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus and remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart, with low levels expressed in liver, brain, lung, thymus and spleen.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TIMP2 (A47) polyclonal antibody detects endogenous levels of TIMP2 protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,

Alternative Name :Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2; TIMP2

Immunogen :Synthetic peptide, corresponding to amino acids 10-60 of Human TIMP-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TIMP2 (A47) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:The lung tissue lysate of Mouse(40ug) Lane4:The lung tissue lysate of Rat(40ug) Lane5:The placenta tissue lysate of Rat(40ug)

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression *

JournalJournal Of Biological Chemistry

ApplicationWB

IF5.157

SpeciesHuman

PMID23897811
CD133 Affects the Invasive Ability of HCT116 Cells by Regulating TIMP-2

JournalAmerican Journal Of Pathology

ApplicationWB

IF3.762

SpeciesHuman

PMID
Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway

JournalToxicology Letters

ApplicationWB

IF3.499

SpeciesHuman

PMID
Strategy of STAT3β cell-specific expression in macrophages exhibits antitumor effects on mouse breast cancer

JournalGene Therapy

ApplicationWB

IF5.25

SpeciesMouse

PMID26181625
Chronic corticosterone exposure induces liver inflammation and fibrosis in association with m 6 A-linked post-transcriptional suppression of heat shock proteins in chicken

JournalCell Stress & Chaperones

ApplicationWB

IF2.892

SpeciesChicken

PMID31745845