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TIMP-2 (A47) polyclonal antibody（KU）

货号: BS1366

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1366

Product Name :TIMP-2 (A47) polyclonal antibody（KU）

Swiss-Prot :P16035

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases 1, 2, 3 and 4) complex with metalloproteinases such as collagenases, gelatin-ases and stromelysins, resulting in irreversible inactivation of the metallopro-teinase. TIMP-1 has been found to be identical to EPA (erythroid-potentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus and remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart, with low levels expressed in liver, brain, lung, thymus and spleen.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :TIMP2 (A47) polyclonal antibody detects endogenous levels of TIMP2 protein.

BiowMW :~ 24 kDa

Note :For research use only, not for use in diagnostic procedure.

Pathway :Tumor Angiogenesis,

Alternative Name :Metalloproteinase inhibitor 2; CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2; TIMP2

Immunogen :Synthetic peptide, corresponding to amino acids 10-60 of Human TIMP-2.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of TIMP2 (A47) polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:HEK293T whole cell lysate(40ug) Lane3:The lung tissue lysate of Mouse(40ug) Lane4:The lung tissue lysate of Rat(40ug) Lane5:The placenta tissue lysate of Rat(40ug)

4-Phenylbutyric acid, a potent endoplasmic reticulum stress inhibitor, attenuates the severity of collagen-induced arthritis in mice via inhibition of proliferation and inflammatory responses of synovial fibroblasts

JournalKaohsiung Journal Of Medical Sciences

ApplicationWB

IF2.744

SpeciesMouse,Human

PMID33759334
The peptide compound urantide regulates collagen metabolism in atherosclerotic rat hearts and inhibits the JAK2/STAT3 pathway

JournalMolecular Medicine Reports

ApplicationWB

IF2.1

SpeciesRat

PMID32016456
Effects of CoCl2‑simulated hypoxia on the expression levels of matrix metalloproteinases in renal adenocarcinoma cells and renal tubular epithelial cells

JournalExperimental and Therapeutic Medicine

ApplicationWB

IF1.785

SpeciesHuman

PMID30116394
The association between activation of the ERK1/2-NF-κB signaling pathway by TIMP2 expression and chronic renal allograft dysfunction in the CRAD rat model

JournalTRANSPLANT IMMUNOLOGY

ApplicationWB,IHC

IF1.5

SpeciesRat

PMID38184210