Product Name :p15 INK4b (G113) polyclonal antibody（KU）
Reactivity :Human,Mouse,Rat
Application_all :WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200
Background :p15 (PAF), also known as PAF, L5, OEATC1 (overexpressed in anaplastic thyroid carcinoma 1) or NS5ATP9, is a 111 amino acid protein that localizes to both the nucleus and the mitochondria. Highly expressed in colon and thymus with lower expression in liver, ovary, kidney, spleen, placenta and small intestine, p15 (PAF) interacts with the nuclear antigen PCNA and, through this interaction, is thought to protect cells from UV-induced cell death. The association of p15 (PAF) and PCNA is enhanced by UV treatment and is facilitated by the binding of ING1, a tumor suppressor that can induce apoptosis.
Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity :p15 INK4b (G113) polyclonal antibody detects endogenous levels of p15 INK4b protein.
Note :For research use only, not for use in diagnostic procedure.
Pathway :Cell Cycle Control G1 S Checkpoint,
Alternative Name :Cyclin-dependent kinase 4 inhibitor B; Multiple tumor suppressor 2; MTS-2; p14-INK4b; p15-INK4b; P15ink4b; CDKN2B; MTS2
Immunogen :Synthetic peptide, corresponding to amino acids 100-150 of Human p15 INK4b.
Modification :Unmodification
