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Neuregulin-1/SMDF (Y4) polyclonal antibody（KU）

货号: BS1173

价格：￥ 1140

货期：现货（1-2个工作日）

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详细信息检测数据实验指南文献

No. :BS1173

Product Name :Neuregulin-1/SMDF (Y4) polyclonal antibody（KU）

Swiss-Prot :Q15491

Host :Rabbit

Reactivity :Human,Mouse,Rat

Applications :WB IHC IF

Application_all :WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200

Background :The neuregulins are a family of ErbB/HER ligands encoded by four genes. Neuregulin-1 gene, NRG1, encodes numerous splice variants with differing transcription initiation sites. Neuregulin-1 includes a range of isoforms with varying glycosylation, regulation of expression and function. Neuregulin-1 splice variants each bear an EGF-like domain, though otherwise have unique domain structures, differing functions and discrete tissue distribution. Six types of Neuregulin-1 isoform groups have been defined based on their structural features. Three types are most often described, type I (ARIA, NDF or HRG), type II (GGF) and type III (SMDF). Neuregulin-1 has been linked to schizophrenia and has diverse neural functions. Neuregulin-1 affects cell migration, the differentiation of neural crest and Schwann cells, and acts to upregulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :SMDF/Neuregulin 1 (Y4) polyclonal antibody detects endogenous levels of SMDF/Neuregulin 1 protein.

BiowMW :~ 44 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; Neuregulin-1; Acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; Glial growth factor; Heregulin; HRG; Neu differentiation factor; Sensory and motor neuron-derived factor; NRG1; GGF; HGL; HRGA; NDF; SMDF

Immunogen :Synthetic peptide, corresponding to the N-terminal of Human Neuregulin-1/SMDF.

Conjugate :Unconjugated

Modification :Unmodification

Western blot (WB) analysis of Neuregulin-1 SMDF (Y4) pAb at 1:1000 dilution Lane1:PC12 whole cell lysate(40ug) Lane2:CT26 whole cell lysate(40ug) Lane3:PC3 whole cell lysate(40ug) Lane4:SK-OVCAR3 whole cell lysate(40ug) Lane5:MCF-7 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Neuregulin-1/SMDF (Y4) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.

Alterations of myelin morphology and oligodendrocyte development in early stage of Alzheimer’s disease mouse model

JournalNeuroscience Letters

ApplicationWB

IF3.046

SpeciesMouse

PMID28174059