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VNN1 polyclonal antibody

货号: AP6008

价格：￥ 1140

货期：现货（1-2个工作日）

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No. :AP6008

Product Name :VNN1 polyclonal antibody

Swiss-Prot :O95497

Host :Rabbit

Reactivity :Human,Mouse

Applications :WB IF

Application_all :WB: 1:500~1:2000 IF: 1:50~1:100

Background :Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.

Product :Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification&Purity :The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage&Stability :Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity :VNN1 polyclonal antibody detects endogenous levels of VNN1 protein.

BiowMW :~ 60 kDa

Note :For research use only, not for use in diagnostic procedure.

Alternative Name :Pantetheinase; Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1; Vanin-1; Vanin 1; Vanin1

Immunogen :Recombinant fusion protein containing a sequence corresponding to amino acids 300-415 of human VNN1 (NP_004657.2).

Conjugate :Unconjugated

Modification :Unmodification

Western blot analysis of extracts of various cell lines, using VNN1 antibody at 1:3000 dilution.

Pharmacological inhibition of Vanin-1 is not protective in models of acute and chronic kidney disease

JournalAmerican Journal Of Physiology-Renal Physiology

ApplicationWB

IF3.377

SpeciesMouse

PMID33196323